Publications

OIRM scientists have been busy publishing their research findings. Below is a sample of their work. This page is updated every month.

Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski SV, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, Rossant J, Gonska T, Moraes TJ, Bear CE. Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia. NPJ Genom Med. 2017 Apr 14;2:12. doi: 10.1038/s41525-017-0015-6. http://www.ncbi.nlm.nih.gov/pubmed/28649446

Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN. Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports. 2017 Jul 11;9(1):1-4. doi: 10.1016/j.stemcr.2017.05.029. http://www.ncbi.nlm.nih.gov/pubmed/28700896

Avey MT, Moher D, Sullivan KJ, Fergusson D, Griffin G, Grimshaw JM, Hutton B, Lalu MM, Macleod M, Marshall J, Mei SH, Rudnicki M, Stewart DJ, Turgeon AF, McIntyre L; Canadian Critical Care Translational Biology Group. The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research. PLoS One. 2016 Nov 17;11(11):e0166733. doi: 10.1371/journal.pone.0166733. eCollection 2016. http://www.ncbi.nlm.nih.gov/pubmed/27855228

Bartoszko J, Panzarella T, McNamara CJ, Lau A, Schimmer AD, Schuh AC, Sibai H, Maze D, Yee KWL, Devlin R, Gupta V. Distribution and Impact of Comorbidities on Survival and Leukemic Transformation in Myeloproliferative Neoplasm-Associated Myelofibrosis: A Retrospective Cohort Study. Clin Lymphoma Myeloma Leuk. 2017 Jun 29. pii: S2152-2650(17)30830-3. doi: 10.1016/j.clml.2017.06.031. http://www.ncbi.nlm.nih.gov/pubmed/28711573

Benoit YD, Mitchell RR, Risueño RM, Orlando L, Tanasijevic B, Boyd AL, Aslostovar L, Salci KR, Shapovalova Z, Russell J, Eguchi M, Golubeva D, Graham M, Xenocostas A, Trus MR, Foley R, Leber B, Collins TJ, Bhatia M. Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Cell Chem Biol. 2017 Jun 21. pii: S2451-9456(17)30189-7. doi: 10.1016/j.chembiol.2017.05.026. http://www.ncbi.nlm.nih.gov/pubmed/28648376

Corbett D, Carmichael ST, Murphy TH, Jones TA, Schwab ME, Jolkkonen J, Clarkson AN, Dancause N, Weiloch T, Johansen-Berg H, Nilsson M, McCullough LD, Joy MT. Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group. Int J Stroke. 2017 Jul;12(5):462-471. doi: 10.1177/1747493017711814. http://www.ncbi.nlm.nih.gov/pubmed/28697710

Djuric U, Rodrigues DC, Batruch I, Ellis J, Shannon P, Diamandis P. Spatiotemporal proteomic profiling of human cerebral development. Mol Cell Proteomics. 2017 Jul 7. pii: mcp.M116.066274. doi: 10.1074/mcp.M116.066274. http://www.ncbi.nlm.nih.gov/pubmed/28687556

Ermini L, Post M, Caniggia I. Statins, Mevalonate Pathway and its Intermediate Products in Placental Development and Preeclampsia. Curr Mol Pharmacol. 2017;10(2):152-160. doi: 10.2174/1874467209666160112123457. Review. http://www.ncbi.nlm.nih.gov/pubmed/26758951

Hopyan S. Biophysical regulation of early limb bud morphogenesis. Dev Biol. 2017 Jun 30. pii: S0012-1606(17)30033-7. doi: 10.1016/j.ydbio.2017.06.034. http://www.ncbi.nlm.nih.gov/pubmed/28669818

Julian LM, McDonald AC, Stanford WL. Direct reprogramming with SOX factors: masters of cell fate. Curr Opin Genet Dev. 2017 Jun 26;46:24-36. doi: 10.1016/j.gde.2017.06.005. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/28662445

Kanda P, Davis DR. Cellular mechanisms underlying cardiac engraftment of stem cells. Expert Opin Biol Ther. 2017 Jul 3:1-17. doi: 10.1080/14712598.2017.1346080. http://www.ncbi.nlm.nih.gov/pubmed/28670973

Khacho M, Slack RS. Mitochondrial and ROS signaling coordinate stem cell fate decisions and life long maintenance. Antioxid Redox Signal. 2017 Jun 28. doi: 10.1089/ars.2017.7228. http://www.ncbi.nlm.nih.gov/pubmed/28657337

Kuljanin M, Bell GI, Sherman SE, Lajoie GA, Hess DA. Proteomic characterisation reveals active Wnt-signalling by human multipotent stromal cells as a key regulator of beta cell survival and proliferation. Diabetologia. 2017 Jul 14. doi: 10.1007/s00125-017-4355-7. http://www.ncbi.nlm.nih.gov/pubmed/28710530

Laksman Z, Wauchop M, Lin E, Protze S, Lee J, Yang W, Izaddoustdar F, Shafaattalab S, Gepstein L, Tibbits GF, Keller G, Backx PH. Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue. Sci Rep. 2017 Jul 13;7(1):5268. doi: 10.1038/s41598-017-05652-y. http://www.ncbi.nlm.nih.gov/pubmed/28706272

Lin AYT, Pearson BJ. Yorkie is required to restrict the injury responses in planarians. PLoS Genet. 2017 Jul 7;13(7):e1006874. doi: 10.1371/journal.pgen.1006874. http://www.ncbi.nlm.nih.gov/pubmed/28686611

Lindqvist J, Torvaldson E, Gullmets J, Karvonen H, Nagy A, Taimen P, Eriksson JE. Nestin contributes to skeletal muscle homeostasis and regeneration. J Cell Sci. 2017 Jul 21. pii: jcs.202226. doi: 10.1242/jcs.202226. http://www.ncbi.nlm.nih.gov/pubmed/28733456

Masoudpour H, Laflamme MA. Cardiac repair with pluripotent stem cell-derived cardiomyocytes: Proof of concept but new challenges. J Thorac Cardiovasc Surg. 2017 Jun 3. pii: S0022-5223(17)31150-9. doi: 10.1016/j.jtcvs.2017.05.088. http://www.ncbi.nlm.nih.gov/pubmed/28688708

Molinski SV, Ahmadi S, Ip W, Ouyang H, Villella A, Miller JP, Lee PS, Kulleperuma K, Du K, Di Paola M, Eckford PD, Laselva O, Huan LJ, Wellhauser L, Li E, Ray PN, Pomès R, Moraes TJ, Gonska T, Ratjen F, Bear CE. Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue. EMBO Mol Med. 2017 Jun 30. pii: e201607137. doi: 10.15252/emmm.201607137 http://www.ncbi.nlm.nih.gov/pubmed/28667089

Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O'Connor M, Lan X, Whetstone H, Coutinho FJ, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai H, Atwal G, Kushida M, Clarke ID, Voisin V, Cusimano MD, Bernstein M, Das S, Bader G, Arrowsmith CH, Angers S, Huang X, Lupien M, Dirks PB. ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. Cell Stem Cell. 2017 Jul 11. pii: S1934-5909(17)30230-8. doi: 10.1016/j.stem.2017.06.004. http://www.ncbi.nlm.nih.gov/pubmed/28712938

Reeve RL, Yammine SZ, Morshead CM, van der Kooy D. Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain. Stem Cells. 2017 Jul 21. doi: 10.1002/stem.2662. http://www.ncbi.nlm.nih.gov/pubmed/28733998

Shlush LI, Mitchell A, Heisler L, Abelson S, Ng SWK, Trotman-Grant A, Medeiros JJF, Rao-Bhatia A, Jaciw-Zurakowsky I, Marke R, McLeod JL, Doedens M, Bader G, Voisin V, Xu C, McPherson JD, Hudson TJ, Wang JCY, Minden MD, Dick JE. Tracing the origins of relapse in acute myeloid leukaemia to stem cells. Nature. 2017 Jun 28. doi: 10.1038/nature22993. http://www.ncbi.nlm.nih.gov/pubmed/28658204

Tassew NG, Charish J, Shabanzadeh AP, Luga V, Harada H, Farhani N, D'Onofrio P, Choi B, Ellabban A, Nickerson PEB, Wallace VA, Koeberle PD, Wrana JL, Monnier PP. Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS. Cell Rep. 2017 Jul 5;20(1):99-111. doi: 10.1016/j.celrep.2017.06.009. http://www.ncbi.nlm.nih.gov/pubmed/28683327

Williams BA, Law AD, Routy B, denHollander N, Gupta V, Wang XH, Chaboureau A, Viswanathan S, Keating A. A phase I trial of NK-92 cells for refractory hematological malignancies relapsing after autologous hematopoietic cell transplantation shows safety and evidence of efficacy. Oncotarget. 2017 Jul 12. doi: 10.18632/oncotarget.19204. http://www.ncbi.nlm.nih.gov/pubmed/28732386

Yau TM, Noiseux N, Sarkissian S. Cell therapies: The next-generation clinical trials.J Thorac Cardiovasc Surg. 2017 Aug;154(2):556-557. doi: 10.1016/j.jtcvs.2017.04.018. http://www.ncbi.nlm.nih.gov/pubmed/28724241

Zhou W, Mahshid SS, Wang W, Vallée-Bélisle A, Zandstra PW, Sargent EH, Kelley SO. Steric Hindrance Assay for Secreted Factors in Stem Cell Culture. ACS Sens. 2017 Apr 28;2(4):495-500. doi: 10.1021/acssensors.7b00136. Epub 2017 Apr 17. http://www.ncbi.nlm.nih.gov/pubmed/28723184