Publications

OIRM scientists have been busy publishing their research findings. Below is a sample of their work. This page will be updated every month.

  • Aghazadeh Y, Nostro MC. Cell Therapy for Type 1 Diabetes: Current and Future Strategies. Curr Diab Rep. 2017 Jun;17(6):37. doi: 10.1007/s11892-017-0863-6. Review. http://www.ncbi.nlm.nih.gov/pubmed/28432571

  • Bakhtyar N, Jeschke MG, Mainville L, Herer E, Amini-Nik S. Acellular Gelatinous Material of Human Umbilical Cord Enhances Wound Healing: A Candidate Remedy for Deficient Wound Healing. Front Physiol. 2017 Apr 4;8:200. doi: 10.3389/fphys.2017.00200. eCollection 2017. http://www.ncbi.nlm.nih.gov/pubmed/28421003

  • Conant G, Lai BFL, Lu RXZ, Korolj A, Wang EY, Radisic M. High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model. Stem Cell Rev. 2017 Apr 20. doi: 10.1007/s12015-017-9736-2. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28429185

  • Dai DF, Danoviz ME, Wiczer B, Laflamme MA, Tian R. Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes. Stem Cells Int. 2017;2017:5153625. doi: 10.1155/2017/5153625. Epub 2017 Feb 27. http://www.ncbi.nlm.nih.gov/pubmed/28421116

  • Glennie RA, Bailey CS, Tsai EC, Noonan VK, Rivers CS, Fourney DR, Ahn H, Kwon BK, Paquet J, Drew B, Fehlings MG, Attabib N, Christie SD, Finkelstein J, Hurlbert RJ, Parent S, Dvorak MF. An analysis of ideal and actual time to surgery after traumatic spinal cord injury in Canada. Spinal Cord. 2017 Apr 18. doi: 10.1038/sc.2016.177. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28418395

  • Gwynne WD, Hallett RM, Girgis-Gabardo A, Bojovic B, Dvorkin-Gheva A, Aarts C, Dias K, Bane A, Hassell JA. Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts. Oncotarget. 2017 Mar 29. doi: 10.18632/oncotarget.16646. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28404880

  • Hodgkinson KM, Kiernan J, Shih AW, Solh Z, Sheffield WP, Pineault N. Intersecting Worlds of Transfusion and Transplantation Medicine: An International Symposium Organized by the Canadian Blood Services Centre for Innovation. Transfus Med Rev. 2017 Mar 22. pii: S0887-7963(17)30008-1. doi: 10.1016/j.tmrv.2017.03.001. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/28385575

  • Hsu WK, Goldstein CL, Shamji MF, Cho SK, Arnold PM, Fehlings MG, Mroz TE. Novel Osteobiologics and Biomaterials in the Treatment of Spinal Disorders. Neurosurgery. 2017 Mar 1;80(3S):S100-S107. doi: 10.1093/neuros/nyw085. http://www.ncbi.nlm.nih.gov/pubmed/28350951

  • Jackson R, Mount S, Ye B, Mayfield AE, Chan V, Boodhwani M, Davies RA, Haddad H, Davis DR. Isolation of human explant derived cardiac stem cells from cryopreserved heart tissue. PLoS One. 2017 Apr 17;12(4):e0176000. doi: 10.1371/journal.pone.0176000. eCollection 2017. http://www.ncbi.nlm.nih.gov/pubmed/28414815

  • Jeschke MG, Peck MD. Burn Care of the Elderly. J Burn Care Res. 2017 Mar 30. doi: 10.1097/BCR.0000000000000535. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28362655

  • Kelly GM, Gatie MI. Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells. Stem Cells Int. 2017;2017:3684178. doi: 10.1155/2017/3684178. Epub 2017 Mar 8. Review. http://www.ncbi.nlm.nih.gov/pubmed/28373885

  • Kepecs DM, Yuen DA, Zhang Y, Thai K, Connelly KA, Gilbert RE. Progenitor cell secretory products exert additive renoprotective effects when combined with ace inhibitors in experimental CKD. J Renin Angiotensin Aldosterone Syst. 2016 Sep 15;17(3). doi: 10.1177/1470320316668434.

  • Krauszman A, Mak T, Szaszi K, Kuebler WM. Role of phosphatase and tensin homolog (PTEN) in hypoxic pulmonary vasoconstriction. Cardiovasc Res. 2017 Apr 18. doi: 10.1093/cvr/cvx076. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28430879

  • Kukumberg M, Yao JY, Neo DJH, Yim EKF. Microlens topography combined with vascular endothelial growth factor induces endothelial differentiation of human mesenchymal stem cells into vasculogenic progenitors. Biomaterials. 2017 Jul;131:68-85. doi: 10.1016/j.biomaterials.2017.03.036. Epub 2017 Mar 27.  https://www.ncbi.nlm.nih.gov/pubmed/28380401

  • Lee JH, Laronde S, Collins TJ, Shapovalova Z, Tanasijevic B, McNicol JD, Fiebig-Comyn A, Benoit YD, Lee JB, Mitchell RR, Bhatia M. Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency. Cell Rep. 2017 Apr 4;19(1):20-35. doi: 10.1016/j.celrep.2017.03.036. http://www.ncbi.nlm.nih.gov/pubmed/28380358

  • Liu J, Pyne DG, Abdelgawad M, Sun Y. Appendix C: Automated Vitrification of Mammalian Embryos on a Digital Microfluidic Device. Methods Mol Biol. 2017;1568:309-316. doi: 10.1007/978-1-4939-6828-2_23. http://www.ncbi.nlm.nih.gov/pubmed/28421507

  • Mahou R, Zhang DK, Vlahos AE, Sefton MV. Injectable and inherently vascularizing semi-interpenetrating polymer network for delivering cells to the subcutaneous space. Biomaterials. 2017 Mar 24;131:27-35. doi: 10.1016/j.biomaterials.2017.03.032. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28371625

  • McFaul CM, Fernandez-Gonzalez R. Shape of my heart: cell-cell adhesion and cytoskeletal dynamics during Drosophila cardiac morphogenesis. Exp Cell Res. 2017 Apr 4. pii: S0014-4827(17)30184-2. doi: 10.1016/j.yexcr.2017.03.057. [Epub ahead of print] Review. http://www.ncbi.nlm.nih.gov/pubmed/28389210

  • McGaugh EC, Nostro MC. Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors. J Vis Exp. 2017 Mar 7;(121). doi: 10.3791/55265. http://www.ncbi.nlm.nih.gov/pubmed/28362406

  • Noonan VK, Chan E, Santos A, Soril L, Lewis R, Singh A, Cheng CL, O'Connell C, Truchon C, Paquet J, Christie S, Ethans K, Tsai E, Ford MH, Drew B, Linassi G, Bailey C, Fehlings MG. Traumatic Spinal Cord Injury Care in Canada: A Survey of Canadian Centres. J Neurotrauma. 2017 Apr 1. doi: 10.1089/neu.2016.4928. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28367684

  • Sartori A, Abdoli M, Freedman MS. Can we predict benign multiple sclerosis? Results of a 20-year long-term follow-up study. J Neurol. 2017 Apr 17. doi: 10.1007/s00415-017-8487-y. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28417192

  • Savla R, Mrsny RJ, Park K, Aubert I, Stamoran C. Insights and Lessons from a Scientific Conference on Non-Invasive Delivery of Macromolecules. Pharm Res. 2017 Apr 6. doi: 10.1007/s11095-017-2156-9. [Epub ahead of print]  http://www.ncbi.nlm.nih.gov/pubmed/28386634

  • Shukla S, Langley MA, Singh J, Edgar JM, Mohtashami M, Zúñiga-Pflücker JC, Zandstra PW. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1. Nat Methods. 2017 Apr 10. doi: 10.1038/nmeth.4258. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28394335

  • Simões S, Oh Y, Wang MF, Fernandez-Gonzalez R, Tepass U. Myosin II promotes the anisotropic loss of the apical domain during Drosophila neuroblast ingression. J Cell Biol. 2017 Mar 31. pii: jcb.201608038. doi: 10.1083/jcb.201608038. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28363972

  • Steinbach SK, Yau TM, Ouzounian M, Abdel-Qadir H, Chandy M, Waddell T, Husain M. Skin-derived precursors from human subjects with type-2 diabetes yield dysfunctional vascular smooth muscle cells. Clin Sci (Lond). 2017 Apr 19. pii: CS20170239. doi: 10.1042/CS20170239. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28424290

  • Tam RY, Smith LJ, Shoichet MS. Engineering Cellular Microenvironments with Photo- and Enzymatically Responsive Hydrogels: Toward Biomimetic 3D Cell Culture Models. Acc Chem Res. 2017 Mar 27. doi: 10.1021/acs.accounts.6b00543. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28345876

  • Turgeon AF, Lauzier F, Zarychanski R, Fergusson DA, Léger C, McIntyre LA, Bernard F, Rigamonti A, Burns K, Griesdale DE, Green R, Scales DC, Meade MO, Savard M, Shemilt M, Paquet J, Gariépy JL, Lavoie A, Reddy K, Jichici D, Pagliarello G, Zygun D, Moore L; TBI-Prognosis Study Team and the Canadian Critical Care Trials Group. Prognostication in critically ill patients with severe traumatic brain injury: the TBI-Prognosis multicentre feasibility study. BMJ Open. 2017 Apr 17;7(4):e013779. doi: 10.1136/bmjopen-2016-013779. http://www.ncbi.nlm.nih.gov/pubmed/28416497

  • Yu J, Guo Q, Mu JB, Zhang T, Li RK, Xie J. Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain. Biomed Environ Sci. 2017 Mar;30(3):185-193. doi: 10.3967/bes2017.026. http://www.ncbi.nlm.nih.gov/pubmed/28427488

  • Zhu Y, Xu L, Collins JJ, Vadivel A, Cyr-Depauw C, Zhong S, Mense L, A Möbius M, Thébaud B. Human Umbilical Cord Mesenchymal Stromal Cells Improve Survival and Bacterial Clearance in Neonatal Sepsis in Rats. Stem Cells Dev. 2017 Apr 12. doi: 10.1089/scd.2016.0329. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/28401804