David Allan

Ongoing research addresses the cellular and molecular determinants of regenerative function in blood-derived vascular progenitor cells. Vascular repair is crucial for tissue regeneration in several models of ischemic tissue injury, including the repair of transplant-related toxicity following bone marrow transplantation (BMT). Ongoing research projects are aimed at understanding the initial stage of vascular progenitor adhesion to the injured microenvironment including interactions with the extracellular matrix and the injured endothelium. We are addressing how initial contact with the injured milieu can facilitate vascular repair. Additional studies focus on the role of mesenchymal stromal cells in immune modulation and tissue repair. Translational research projects and clinical trials involving blood-derived stem cells also comprise an important aspect of Dr. Allan’s research program. Research in Dr. Allan’s laboratory is funded by CIHR, NSERC, Canadian Blood Services, The Ottawa Hospital Foundation and the Department of Medicine at the University of Ottawa.