Profile and Department: Associate Professor, Physiology & Pharmacology, University of Western Ontario
Lab: Betts Lab
Cellular Aging and Reprogramming Laboratory
We are interested in understanding the cellular and molecular basis of cellular senescence and to examine/evaluate the epigenetic reprogramming events necessary to reverse cellular aging and differentiation in the production of induced pluripotent stem cells. A focus of the lab is to train the next generation of scientists. The Betts Lab uses unique cell / embryo models and molecular cell biology techniques to study cellular senescence and reprogramming in embryos, stem cells and aged somatic cells. This research program aims to further our understanding of the cell aging process and it’s modulation. These studies will evaluate the normalcy and safety of the cellular products generated for transplantation therapies and will elucidate the potential for cellular aging to be prevented, slowed down or even reversed.
· The role of p66Shc in ROS-mediated cellular senescence and reprogramming.
· The role of TERT splice variants in pluripotency and self-renewal.
· The role of premature senescence in intrauterine growth restriction (IUGR) outcomes.
· Generation of induced pluripotent stem cells (iPSCs) from umbilical cord blood stem cells.
· Development of stem cell technologies in domestic animals such as the horse and dog.