Profile and Department: Professor, Physics, University of Toronto
Lab: Goyal Lab
A significant knowledge about the molecular mechanism involved in production of functioning blood and immune cells from a hematopoietic stem cell (HSC) has been gleaned from recent cell-level experiments. However, how a population of such HSCs organize together to maintain stable blood generation at the whole-animal level is a central question in animal physiology with implications for blood related diseases including blood cancers. Based on long-term repopulation data, we are developing an animal-level mathematical model for blood regeneration with the eventual goal of providing a framework with which to quantitatively study perturbations and genetic modifications of the hematopoietic system.