Clinical Trials

OIRM supports cell therapy clinical trials in Ontario through funding for its large Disease Teams program. Currently, OIRM is directly supporting one clinical trial (septic shock) and several other research projects where clinical trials may launch in 1-4 years. Through programs and workshops led by OIRM’s Clinical Translation Initiative, we help build capacity and expertise for new clinical trials to find success in the future.

In addition, through the ongoing research at The Ottawa Hospital, a small number of patients with severe autoimmune diseases have been treated using chemotherapy and blood stem cell transplants outside of clinical trials and supported through the provincial health care system. The diseases are:

If you are a patient or caregiver seeking information about clinical trials, we recommend you review our About Clinical Trials page. For more information about current and upcoming clinical trials in Ontario, see the list below.

Current Ontario clinical trials

Duncan Stewart – OHRI

Investigators Trial Name (click for more information) Condition Phase
Mark Freedman and Harry Atkins – OHRI Safety and efficacy of intravenous autologous mesenchymal stem cells for MS: a phase 2 proof of concept study (MESCAMS) Multiple Sclerosis II
Terry Yau – UHN Safety and efficacy of intramyocaridal injection of mesenchymal precursor cells on myocardial function in left ventricular assist device receipients Heart failure II
Duncan Stewart – OHRI The enhanced angiogenic cell therapy – acute myocardial infarction trial (ENACT-AMI) Heart failure II
Gary Levy- UHN Autologous Hematopoietic Stem Cell Transplantation for Allogenic Organ Transplant Tolerance (ASCOTT) Liver transplant II-III
Duncan Stewart- OHRI SAPPHIRE Trial for Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension II

This trial listing is also available in the graphic format for download and sharing. Click the link below.

Trials launching soon:

Investigators Trial Name  Condition Phase
Lauralyn McIntyre – OHRI Cellular immunotherapy for septic shock-(CISS2): A Phase II Multicenter Clinical Trial Septic Shock II
Don Mabbott – SickKids Metformin for Motor and Cognitive Improvement in Children with Cerebral Palsy Cerebral Palsy II
Ann Yeh and Don Mabbott – SickKids Metformin to stimulate brain repair in children with Multiple Sclerosis Multiple Sclerosis II

Recently completed trials:

Investigators Trial Name  Condition Phase
Lauralyn McIntyre – OHRI Cellular immunotherapy for septic shock (CISS): A Phase I Trial Septic Shock I
Terrence Yau – UHN IMPACT-CABG Trial: IMPlantation of Autologous CD133+ sTem Cells in Patients Undergoing Coronary Artery Bypass Grafting (IMPACT-CABG) Heart Failure II
Jas Chahal & Sowmya Viswanathan – UHN Human autologous MSCs for the treatment of mid to late stage knee OA Osteoarthritis I-II
Don Mabbott – SickKids Placebo controlled double blind crossover trial of metformin for brain repair in children with cranial-spinal radiation for medullablastoma Brain tumours III
Alan Getgood – Fowler Kennedy Sports Medicine Clinic Confirmatory Study of NeoCart in Knee Cartilage Repair Cartilage repair in joints III
Armand Keating – UHN Safety study looking at the use of genetically-modified autologous stem cells for the treatment of males with Fabry disease Fabry Disease I