Department: Physiology, University of Toronto
Lab: Gramolini Lab
A major interest of our lab is to investigate the cellular mechanisms involved in the regulation of calcium cycling at the level of sarcoplasmic reticulum and its role in cardiac disease. For these experiments, we apply conventional biochemical and molecular biology assays and digital confocal imaging. Model systems include established cell lines, primary cell cultures and transgenic animals. These techniques serve as valuable experimental tools to investigate PLN mutations, cellular protein sorting and Ca2+ cycling.