John Coles
Profile: Senior Associate Scientist, SickKids Research Institute
Department: Surgery, University of Toronto
Research Interests:
Our research studies are directed towards understanding the molecular biology of hypertrophy, which occurs in congenital heart disease. We are specifically focused on signaling cascades, which promote beneficial compensatory cardiac hypertrophy. Our lab is also focused on the characterization of cardiac-progenitor cells resident within the heart in congenital heart disease. Both areas of study involve mouse models of cardiac hypertrophy and parallel analysis of clinical samples exhibiting various degrees and types of hypertrophy.