Profile: Senior Scientist, Regenerative Medicine Program, Ottawa Hospital Research Institute
Department: Medicine and Cellular and Molecular Medicine, University of Ottawa
Lab: Megeney Lab
Dr. Megeney’s research has had significant impact in an area of basic cellular biology with the discovery that cell death or apoptotic pathways play vital roles in normal biologic processes such as stem cell differentiation. Dr. Megeney has extended these observations to demonstrate that cell death proteins evolved from non death roles in single cell organisms. Collectively, this work has overturned basic precepts in biology and given rise to an entirely new area of investigation. Work in the Megeney lab continues to explore the mechanisms by which caspase proteases regulate stem cell self-renewal and how these ‘pro-death’ proteins manage proteostasis and promote stress adaptation.