Stem Cell Bioengineering aims to develop quantitative and predictive descriptions of stem cell fate processes, and to use of this information in the design and implementation of beneficial stem cell-based technologies. Research in the Stem Cell Bioengineering Laboratory is focused on understanding the interface between microenvironmental control and the endogenous (niche-mediated) and intracellular networks that underlie stem cell fate decisions. We are motivated by the hypothesis that the appropriate engineering of the cellular microenvironment will enable robust and efficient manipulation of stem cell self-renewal and differentiation. Using bioengineering strategies such as predictive mathematical modeling, microfabrication and bioreactors, our work is applied to three project areas: quantitative, spatial and temporal control of embryonic stem cell self-renewal; bioprocesses for the generation of blood and cardiac cells from embryonic stem cells; and control of intercellular signaling networks to grow human blood stem cells. Ultimately, our goal is to enable stem cell based therapies and technologies and thus positively impact upon health and welfare.