Our Research

Ontario has a distinguished history of ground-breaking discoveries in the stem cell field, dating back to the seminal discoveries of Till and McCulloch in Toronto in the early 1960s. Till and McCulloch proved the existence of blood stem cells and provided the rigorous and quantitative foundation upon which stem cell biology is studied around the world today. Globally, Canada ranks third in terms of the influence of its research according to impact factor, which is measured by the number of times a publication is referenced by other researchers (Thomson-Reuters 2005-2010).

OIRM has over 170 scientists across the province, including stem cell bioloigists, biomaterial engineers and translational clinicians. This collaborative expertise also created the foundation for the eight Disease Teams listed below:

  • Blood Stem Cell-based Therapeutics
  • Cartilage and Bone
  • Lung Disease
  • Neural Repair
  • Cardiovascular Disease
  • Diabetes
  • Muscle Regeneration
  • Vision

OIRM is open to other areas of disease focus as it continues to launch its strategic investments. OIRM Disease Teams focus on areas of current large costs to the healthcare system but also substantial global opportunities for improved treatments and outcomes based on regenerative medicine. For most of the disease foci, Ontario is at the leading edge in research activities, clinical programs and new commercialization efforts that are moving the field forward. This includes ground-breaking cell therapy clinical trials, drug development, technologies for manufacturing cells and small molecules that can enhance the body’s own stem cells.